timi天美传孟若羽

团队介绍：

本人于2005年timi天美传孟若羽泌尿外科博士研究生毕业并留院工作。多年来一直从事泌尿男科医教研工作，包括男性勃起功能障碍、男性射精功能障碍、男性不育症、精索静脉曲张、性腺功能异常等。在J Urol、Andrology、J Sex Med等国际泌尿男科专业知名期刊发表数十篇研究论文。参编著作7部，主译（副）1部。现承担国家自然科学基金面上项目、北京市自然科学基金面上项目和横向课题各一项。 

学术任职：

中国性学会性医学分会副主委、

中国非公立医疗机构协会男科专委会主任委员、

亚太性学会础笔厂厂惭执行委员、

中华医学会男科学分会第七届委员会男性性功能障碍学组委员、

中国医疗保健国际交流促进会生殖感染与微生态分会委员、

北京医师协会男科专科医师分会常务理事、

北京市医学会男科学分会青年委员会副主委、

北京中西医结合学会男科专业委员会青年委员会副主委。

重大奖励：

1. 2015年 中国医师协会男科医师分会优秀青年男科医师奖

2. 2018年 华夏医学科技奖三等奖（项目名称：淫羊藿苷及淫羊藿次苷II防治勃起功能障碍的药理药效及作用机理）

3. 2019年 第三届国之名医盛典 “国之名医.优秀风范”奖

项目情况：

主要集中在中药单体包括熊果酸、淫羊藿次苷滨滨等在改善勃起功能障碍中的作用及分子机制研究。运用蛋白质组学、转录组学、单细胞测序组学等多组学重点阐述中药单体小分子的潜在作用靶点。

招生信息（拟招生的研究方向）：

男性勃起功能障碍发病机理

科研项目：

在研主持项目:

1. 熊果酸调控VEGF/eNOS/NO通路促进血管新生治疗勃起功能障碍的作用与机制 国家自然科学基金面上项目 2022.01- 2025.12 

2. 熊果酸调控阴茎内源性干细胞激活分化改善大鼠勃起功能障碍的机制研究 北京市自然科学基金面上项目 2022.01- 2024.12

代表性研究成果：

近5年发表文章：

1 Tan X H, Gu Y Y, Song W P, Nan T G, Song W D, Fang D, Yuan Y M, Xin Z C, Li X S, Guan R L. Transcriptome analysis highlights the role of ferroptosis in palmitic acid-induced endothelial dysfunction [J]. Sex Med, 2023, 11(1): qfac008.

2 Tan X H, Gu S J, Tian W J, Song W P, Gu Y Y, Yuan Y M, Li X S, Xin Z C, Kim S W, Guan R L, Bae W J. Extracellular vesicles derived from human Sertoli cells: characterizations, proteomic analysis, and miRNA profiling [J]. Mol Biol Rep, 2022, 49(6): 4673-4681.

3 Song W, Yuan Y, Tan X, Gu Y, Zeng J, Song W, Xin Z, Fang D, Guan R. Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways [J]. PeerJ, 2022, 10: e14192.

4 Gu Y Y, Tan X H, Song W P, Song W D, Yuan Y M, Xin Z C, Wang J D, Fang D, Guan R L. Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway [J]. Front Pharmacol, 2022, 13: 920601.

5 Fang D, Tan X H, Song W P, Gu Y Y, Pan J C, Yang X Q, Song W D, Yuan Y M, Peng J, Zhang Z C, Xin Z C, Li X S, Guan R L. Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction [J]. Front Endocrinol (Lausanne), 2022, 13: 874915.

6 Yuan Y, Fang D, Lei H, Li M, Cheng W, Gao B, Peng J, Zhang Z, Xin Z, Guo Y. Rat model and validation of a modified single-armed suture technique for microsurgical vasoepididymostomy: Guo's SA-LIVE [J]. Andrology, 2021, 9(1): 361-367.

7 Tan X H, Fang D, Xu Y D, Nan T G, Song W P, Gu Y Y, Gu S J, Yuan Y M, Xin Z C, Zhou L Q, Guan R L, Li X S. Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via "Salting-Out": Characterizations and Potential Functions as Nanocarriers [J]. Front Nutr, 2021, 8: 769223.

8 Jin M, Yuan S, Yuan Y, Yi L. Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis [J]. Front Oncol, 2021, 11: 735803.

9 Gu S J, Li M, Yuan Y M, Xin Z C, Guan R L. A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury [J]. Andrology, 2021, 9(6): 1893-1901.

10 Fang D, Peng J, Liao S, Tang Y, Cui W, Yuan Y, Wu D, Hu B, Wang R, Song W, Gao B, Jin L, Zhang Z. An Online Questionnaire Survey on the Sexual Life and Sexual Function of Chinese Adult Men During the Coronavirus Disease 2019 Epidemic [J]. Sex Med, 2021, 9(1): 100293.

11 Chung E, Jiann B P, Nagao K, Hakim L, Huang W, Lee J, Lin H, Mai D B T, Nguyen Q, Park H J, Sato Y, Tantiwongse K, Yuan Y, Park K. COVID Pandemic Impact on Healthcare Provision and Patient Psychosocial Distress: A Multi-National Cross-Sectional Survey among Asia-Pacific Countries [J]. World J Mens Health, 2021, 39(4): 797-803.

12 Peng J, Fang D, Li H, Tang Y, Yuan Y, Cui W, Gao B, Li H, Zhang Z. Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice [J]. BMC Urol, 2020, 20(1): 11.

13 Li M, Yuan Y M, Yang B C, Gu S J, Li H X, Xin Z C, Fang D, Guan R L. Comparative study of intracavernous pressure and cavernous pathology after bilateral cavernous nerve crushing and resection in rats [J]. Asian J Androl, 2020, 22(6): 629-635.

14 Chung E, Jiann B P, Nagao K, Hakim L, Huang W, Lee J, Lin H, Tien Mai D B, Nyugen Q, Park H J, Sato Y, Tantiwongse K, Yuan Y, Park K. Provision of Sexual Medicine Services During the Coronavirus Disease-2019 Pandemic: An Asia Pacific Society of Sexual Medicine Position Statement [J]. Sex Med, 2020, 8(3): 325-326.

15 Chen S, Wang G, Zheng X, Ge S, Dai Y, Ping P, Chen X, Liu G, Zhang J, Yang Y, Zhang X, Zhong A, Zhu Y, Chu Q, Huang Y, Zhang Y, Shen C, Yuan Y, Yuan Q, Pei X, Cheng C Y, Sun F. Whole-exome sequencing of a large Chinese azoospermia and severe oligospermia cohort identifies novel infertility causative variants and genes [J]. Hum Mol Genet, 2020, 29(14): 2451-2459.

16 Bao Z, Du Y, Yuan Y, Zhu Y, Qian C, Zhan Y, Fang D, Xiong G, Zhang L, Li X, Zhou L. Prevalence, clinicopathological features, and prognosis in upper tract urinary carcinoma patients with severe preoperative chronic kidney disease [J]. Transl Androl Urol, 2019, 8(6): 641-650.