timi天美传孟若羽

团队介绍：

2011-2013年在北京大学泌尿外科研究所在站博士后研究，后留所工作至今，主要从事男性勃起功能障碍发生和发展的分子机制与治疗的研究工作。在包括 Andrology、Asian journal of andrology等著名男科学期刊上发表SCI论文30余篇；近5年承担国家自然科学基金面上项目2项；参与北京市自然科学基金2项，曾获华夏医学科技三等奖一项（排名第二）；已授权国家发明专利一项（排名第一）。现任中国医促会泌尿男性生殖医学分会委员。

项目情况：

在研项目：国家自然科学基金委员会, 面上项目, 扁柏双黄酮联合淫羊藿次苷II激活eNOS/NO信号通路改善大鼠勃起功能障碍的作用机制研究, 2023-01-01 至 2026-12-31

招生信息（拟招生的研究方向）：

男性勃起功能障碍的分子发病机制

科研项目：

近五年主持科研项目课题：

1. 国家自然科学基金委员会, 面上项目, 扁柏双黄酮联合淫羊藿次苷II激活eNOS/NO信号通路改善大鼠勃起功能障碍的作用机制研究, 2023-01-01 至 2026-12-31 

2. 国家自然科学基金委员会, 面上项目, 淫羊藿次苷II调控MAPK信号通路激活阴茎原位内皮祖细胞的机制研究, 2020-01-01 至 2023-12-31

代表性研究成果：

近5年发表文章：

[1] Tan X H, Gu Y Y, Song W P, Nan T G, Song W D, Fang D, Yuan Y M, Xin Z C, Li X S, Guan R L*. (2023). Transcriptome analysis highlights the role of ferroptosis in palmitic acid–induced endothelial dysfunction. Sexual Medicine, 11(1).

[2] Fang D#, Tan X H#, Song W P, Gu Y Y, Pan J C, Yang X Q, Song W D, Yuan Y M, Peng J, Zhang Z C, Xin Z C, Li X S*, Guan R L*. Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction [J]. Front Endocrinol (Lausanne), 2022, 13(874915.

[3] Tan X H#, Gu S J#, Tian W J, Song W P, Gu Y Y, Yuan Y M, Li X S, Xin Z C, Kim S W, Guan R L*, Bae W J*. Extracellular vesicles derived from human Sertoli cells: characterizations, proteomic analysis, and miRNA profiling [J]. Mol Biol Rep, 2022.

[4] Gu Y-Y#, Tan X-H#, Song W-P, Song W-D, Yuan Y-M, Xin Z-C, Wang J-D*, Fang D*, Guan R-L*. Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway [J]. Frontiers in Pharmacology, 2022, 13

[5] Tan X H#, Fang D#, Xu Y D#, Nan T G, Song W P, Gu Y Y, Gu S J, Yuan Y M, Xin Z C, Zhou L Q, Guan R L*, Li X S*. Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via "Salting-Out": Characterizations and Potential Functions as Nanocarriers [J]. Front Nutr, 2021, 8(769223.

[6] Song W P#, Gu S J#, Tan X H, Gu Y Y, Song W D, Zeng J Y, Xin Z C, Guan R L*. Proteomic analysis and miRNA profiling of human testicular endothelial cell-derived exosomes: the potential effects on spermatogenesis [J]. Asian journal of andrology, 2021

[7] Gu S J, Li M, Yuan Y M, Xin Z C*, Guan R L*. A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury [J]. Andrology, 2021, 9(6): 1893-1901.

[8] Cui W S#, Guan R L#, Lei H E, Liu J H, Wang T, Zhu S N, Yao C, Wang J, Feng Y H, Tian L, Xin Z C. Efficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial [J]. Translational andrology and urology, 2021, 10(8): 3358-3367.

[9] Xu Y, Yang Y, Zheng H, Huang C, Zhu X, Zhu Y, Guan R, Xin Z, Liu Z, Tian Y. Intracavernous injection of size-specific stem cell spheroids for neurogenic erectile dysfunction: Efficacy and risk versus single cells [J]. EBioMedicine, 2020, 52(102656.

[10] Li M#, Yuan Y M#, Yang B C, Gu S J, Li H X, Xin Z C, Fang D*, Guan R L*. Comparative study of intracavernous pressure and cavernous pathology after bilateral cavernous nerve crushing and resection in rats [J]. Asian journal of andrology, 2020, 22(6): 629-635.

[11] Chen Y, Cai Q, Pan J, Zhang D, Wang J, Guan R, Tian W, Lei H, Niu Y, Guo Y, Quan C, Xin Z. Role and mechanism of micro-energy treatment in regenerative medicine [J]. Translational andrology and urology, 2020, 9(2): 690-701.

[12] Yang B, Li M, Lei H, Xu Y, Li H, Gao Z, Guan R*, Xin Z*. Low Intensity Pulsed Ultrasound Influences the Myogenic Differentiation of Muscle Satellite Cells in a Stress Urinary Incontinence Rat Model [J]. Urology, 2019, 123(297.e291-297.e298.

[13] Cui W#, Li H#, Guan R, Li M, Yang B, Xu Z, Lin M, Tian L, Zhang X, Li B, Liu W, Dong Z, Wang Z, Zheng T, Zhang W, Lin G, Guo Y, Xin Z. Efficacy and safety of novel low-intensity pulsed ultrasound (LIPUS) in treating mild to moderate erectile dysfunction: a multicenter, randomized, double-blind, sham-controlled clinical study [J]. Translational andrology and urology, 2019, 8(4): 307-319.

获奖情况：

淫羊藿苷及淫羊藿次苷Ⅱ防治勃起功能障碍的药理药效及作用机理，华夏医学科技奖，三等奖, 2018.11，辛钟成、关瑞礼、李辉喜、袁亦铭

发明专利：

一种从牛奶中提取细胞外囊泡的方法，20220614，关瑞礼、谭晓辉、方冬、李学松、周利群