timi天美传孟若羽

团队介绍：

闫婕，timi天美传孟若羽妇产生殖医学中心副主任，北京大学医学博士，瑞典卡罗林斯卡医学院理学博士，美国芝加哥大学访问学者，北京市优秀人才培养资助青年拔尖个人。主要参与妊娠期糖尿病的管理和研究工作。任厂罢础搁（临床实践指南科学性、透明性和适用性的评级工具）专业委员会副主委，中华预防医学会－生命早期发育与疾病防控专业委员会委员兼副秘书长，中华围产医学会感染与免疫学组委员，《母胎医学杂志（英文）》第二届编辑委员会编辑委员，《中国医学伦理学》杂志青年编委及审稿专家。

项目情况：

作为课题负责人，先后承担国家自然科学基金，北京市自然科学基金，教育部留学回国人员科研启动基金，北京市优秀人才培养资助青年拔尖个人项目，北京大学医学青年科技创新发展平台基金，“十四五”国家重点研发计划的项目骨干。参与起草撰写“胎盘植入性疾病”专家共识和“妊娠期糖尿病”临床指南。

招生信息（拟招生的研究方向）：

妊娠期相关疾病的临床干预研究、妊娠期相关疾病的表观遗传学发病机制探讨、母胎互作机制及胎盘营养物质转运机制

科研项目：

1.&苍产蝉辫;国家自然科学基金项目，搁狈础去甲基化酶通过调控厂滨碍1的搁狈础甲基化水平参与妊娠高血糖疾病的胎盘合胞化机制研究，主持

2.&苍产蝉辫;国家重点研发计划，母体内分泌代谢对子代早期健康的影响及关键机制研究，项目骨干

3.&苍产蝉辫;北京市自然科学基金项目，运动干预降低妊娠期糖尿病发生的表观遗传学机制，主持

4.&苍产蝉辫;北京大学医学青年科技创新发展平台基金-青年培育基金，运动干预降低妊娠期糖尿病发生的表观遗传学机制，主持

5.&苍产蝉辫;timi天美传孟若羽青年临床研究专项，早孕期开始强化生活方式干预对预防妊娠期糖尿病再次发生的作用，主持

6.&苍产蝉辫;北京市优秀人才培养资助青年拔尖个人项目，主持

7.&苍产蝉辫;国家自然科学基金项目，表观遗传学对妊娠期糖尿病子代的早期编程作用，主持

8.&苍产蝉辫;北京市自然科学基金项目，妊娠期糖尿病子代炎症基因表达的表观遗传学调控，主持

9.&苍产蝉辫;教育部留学回国人员科研启动基金，表观遗传学对暴露于宫内高血糖环境子代远期表型传代作用，主持

10. Improving Competency-based Undergraduate Medical Education in the 8-Year Medical Education Program (EYMEP) of China for the Transition to Residency Education, China Medical Board (CMB), Co-PI

11. timi天美传孟若羽国自然培育基金，探究 RNA甲基化调控葡萄糖转运从而参与妊娠期糖尿病疾病发生的机制，主持

代表性研究成果：

1. Yan, J., C. Wang, Y. Wei and H. Yang (2023). "Exercise intervention during pregnancy induces DNA methylation alterations in maternal blood and cord blood." Chin Med J (Engl). 2023 Feb 7.

2. Wei, J., J. Yan and H. Yang (2022). "Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Nutrients 14(14). (共同一作)

3. Jauniaux, E., J. Yan and A. T. Papageorghiou (2022). "Aortic balloon for the intra-operative management of placenta accreta spectrum: need for standardised methodology and safety data." BJOG 129(1): 149-150.

4. Zheng, W., H. Zhang, J. Ma, R. Dou, X. Zhao, J. Yan and H. Yang (2022). "Validation of a scoring system for prediction of obstetric complications in placenta accreta spectrum disorders." J Matern Fetal Neonatal Med 35(21): 4149-4155. (共同通讯)

5. Yang, X., W. Zheng, H. Zhang, X. Wei, J. Yan and H. Yang (2021). "Expectant management of cesarean scar pregnancy in 13 patients." J Matern Fetal Neonatal Med: 1-6. (共同通讯)

6. Yang, H. X., J. Yan, X. X. Liu, D. J. Chen and Y. Y. Zhao (2021). "[The standardized terminology and clinical diagnosis on "placenta accrete spectrum disorders" in China]." Zhonghua Fu Chan Ke Za Zhi 56(6): 377-379.

7. Yan, J., L. Wang, Y. Yang, Y. Zhang, H. Zhang, Y. He, Z. Peng, Y. Wang, Q. Wang, H. Shen, Y. Zhang, D. Yan, X. Ma and H. Yang (2020). "The trend of caesarean birth rate changes in China after 'universal two-child policy' era: a population-based study in 2013-2018." BMC Med 18(1): 249.

8. Yan, J., J. Guo, C. Fan, J. Juan, X. Yu, J. Li, L. Feng, C. Li, H. Chen, Y. Qiao, D. Lei, C. Wang, G. Xiong, F. Xiao, W. He, Q. Pang, X. Hu, S. Wang, D. Chen, Y. Zhang, L. C. Poon and H. Yang (2020). "Coronavirus disease 2019 in pregnant women: a report based on 116 cases." Am J Obstet Gynecol 223(1): 111 e111-111 e114.

9. Yan, J., R. Su, W. Zhang, Y. Wei, C. Wang, L. Lin, H. Feng and H. Yang (2019). "Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia." J Matern Fetal Neonatal Med: 1-10.

10. Yan, J., R. Su, D. Ao, Y. Wang, H. Wang and H. Yang (2018). "Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study." J Matern Fetal Neonatal Med 31(16): 2115-2121.

11. Yan, J., H. Yang, W. Meng, Y. Wang, L. Shang, Z. Cai, L. Ji, Y. Wang, Y. Sun, J. Liu, L. Wei, Y. Sun, X. Zhang, T. Luo, H. Chen, L. Yu, X. Liu, Z. Wang and H. Chen (2018). "Abdominal circumference profiles of macrosomic infants born to mothers with or without hyperglycemia in China." J Matern Fetal Neonatal Med: 1-8.

12. Su, R., J. Yan and H. Yang (2016). "Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia." J Diabetes Res 2016: 4952801. (共同一作)

13. Yan, J., C. Y. Shi, L. Yu and H. X. Yang (2015). "Folding Sutures Following Tourniquet Binding as a Conservative Surgical Approach for Placenta Previa Combined with Morbidly Adherent Placenta." Chin Med J (Engl) 128(20): 2818-2820.

14. Yan, J. and H. Yang (2014). "Gestational diabetes in China: challenges and coping strategies." Lancet Diabetes Endocrinol 2(12): 930-931.

15. Yan, J. and H. Yang (2014). "Gestational diabetes mellitus, programing and epigenetics." J Matern Fetal Neonatal Med 27(12): 1266-1269.

16. Yan, J., X. Li, R. Su, K. Zhang and H. Yang (2014). "Long-term effects of maternal diabetes on blood pressure and renal function in rat male offspring." PLoS One 9(2): e88269.

17. Yan, J., Y. Shi, C. Sun and H. Yang (2013). "Vitamin K treatment of brodifacoum poisoning in a pregnant woman." Int J Gynaecol Obstet 122(2): 162-163.

18. Barres, R., J. Yan, B. Egan, J. T. Treebak, M. Rasmussen, T. Fritz, K. Caidahl, A. Krook, D. J. O'Gorman and J. R. Zierath (2012). "Acute exercise remodels promoter methylation in human skeletal muscle." Cell Metab 15(3): 405-411.

19. Yan, J., J. R. Zierath and R. Barres (2011). "Evidence for non-CpG methylation in mammals." Exp Cell Res 317(18): 2555-2561.

20. Barres, R., M. E. Osler, J. Yan, A. Rune, T. Fritz, K. Caidahl, A. Krook and J. R. Zierath (2009). "Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density." Cell Metab 10(3): 189-198.