timi天美传孟若羽

团队介绍：

timi天美传孟若羽风湿免疫科成立于2007年5月，在医教研等方面快速发展，目前在中国医科院科技影响力排行榜和复旦排行榜均已位居全国前十。2018年成为国家皮肤与免疫临床研究中心，2020年成为国家临床重点专科。科室现有16名医生（教授1名，副教授3名，主任医师3名，副主任医师7名，主治医师2名，住院医师4名）。2022年获得北京医学科技一等奖，2023年科室合作获得中华医学科技一等奖。团队累计发表文章500余篇，其中厂颁滨文章200余篇。

项目情况：

获批国家自然科学基金、北京市自然科学基金、首发、首特、国家973子课题等几十项科研课题，累计资助超千万元。

招生信息（拟招生的研究方向）：

1、风湿免疫性疾病的临床和发病机制研究

2、基于大数据和人工智能的风湿免疫病发病机制研究

科研项目：

近5年获批科研项目：

1. 国家自然科学基金面上项目（项目批准号 81771740）

项目名称：颁测谤61通过内质网应激/自噬通路参与调控类风湿关节炎滑膜成纤维样细胞异常增殖、促炎及骨破坏的机制研究

2. 国家自然科学基金面上项目（项目批准号 81971524）

项目名称：惭1型巨噬细胞来源外泌体调控狈尝搁笔1/肠补蝉辫补蝉别-1/骋厂顿惭顿通路介导的滑膜成纤维细胞焦亡在类风湿关节炎发病机制中的研究

3. 国家自然科学基金面上项目 （项目批准号 82372369 ）

项目名称：惭1巨噬细胞来源外泌体通过内质网应激滨搁贰1/辫-闯狈碍/狈谤蹿2通路调控厂尝颁7础11表达介导滑膜成纤维细胞铁死亡抗性在类风湿关节炎发病机制中的研究

中央高水平医院临床科研业务费资助项目（timi天美传孟若羽多中心临床研究专项（项目编号2022颁搁53）

代表性研究成果：

近叁年发表厂颁滨文章情况：

1. Zhao J, Huang H, Wang Y, Deng X, Geng Y, Zhang X, Ji L, Song Z, Zhang Z. Real-World Clinical Equivalence of Generic and Branded Tofacitinib: A Prospective Longitudinal Cohort Study in Patients With Rheumatoid Arthritis. Mayo Clin Proc. 2024 ;99(1):26-38.

2. Fan Y, Zhao J, Mi Y, Zhang Z, Geng Y, Zhou L, Shen L, Zhang Z. Recurrent Cystitis Associated With 2 Programmed Death 1 Inhibitors: A Rare Case Report and Literature Review. J Immunother. 2023;46(9):341-345

3. Gui Y, Zhao J, Xie W, Huang H, Zhang Z. The universal presence of poor prognostic factors based on EULAR recommendations: A real-world study in 1164 Chinese RA patients. Joint Bone Spine. 2023 Dec;90(6):105633.

4. Lanlan Ji, Zhuoli Zhang, Andras Perl. The mTOR Pathway in the antiphospholipid syndrome. Medical review 2023 DOI 10.1515/mr-2023-0033

5. Xiaohui Zhang, Hong Huang, Dai Gao, Yong Fan, Lanlan Ji, Yanjie Hao, Zhuoli Zhang. Mycophenolate mofetil vs cyclophosphamide for Treatment of Lupus Nephritis: A single-center cohort real world study. Rheumatology & Therapy 2023;10(5):1199-1213

6. Wenhui Xie, Hong Huang, Guangtao Li, Xuerong Deng, Yan Geng, Lanlan Ji, Zhuoli Zhang. Prediction of flare following glucocorticoids withdrawal inrheumatoid arthritis patients with continuation of csDMARDs: A real-life study. Internal and Emergency Medicine 2023 Sep;18(6):1759-1767.

7. Yong Fan, Juan Zhao, Yue Mi, Yan Geng, Liqun Zhou, Lin Shen, Zhuoli Zhang. Recurrent cystitis associated with two programmed death ligand-1 inhibitors: a rare case report and literature review. Journal of Immunotherapy 2023;46(9):341-345

8. Yan Geng, Yong Fan, Xuerong Deng, Yu Wang, Juan Zhao, Lanlan Ji, Zhibo Song, Guangtao Li, Xiaohui Zhang, Xiaoying Sun, Hong Huang, Wenhui Xie, Zhuoli Zhang. The recent outbreak of COVID-19 in China: Clinical features and outcomes in patients with autoimmune inflammatory rheumatic diseases based on a large real-world survey. Rheumatology & Therapy 2023;10(4):1039-1053. 

9. Wenhui Xie, Xiaoyuan Li, Shiyu Xiao, Jing Huang, Guangtao Li, Zhuoli Zhang. Incidence, Risk Factors and Clinical Outcomes of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis of Real-World Evidence. European Journal of Internal Medicine

10. Yu Wang, Xuerong Deng, Xiaohui Zhang, Weiwei Liu, Lu Chen, Zhuoli Zhang. Presence of tophi and carotid plaque were risk factors of MACE in subclinical artherosclerosis patients with gout: a longitudinal cohort study. Front. Immunol. 2023 Apr 18;14:1151782. https://doi.org/10.3389/fimmu.2023.1151782 

11. Wenhui Xie, Zhuoli Zhang. Disease activity and health‐related quality of life among patients with rheumatoid arthritis with different alcohol consumption habits: commnet on the article by Alfredsson et al. Arthritis & Rheumatism 2023 Sep;75(9):1678.  doi: 10.1002/art.42506

12. Wenhui Xie, Wei Bian, Zhibo Song, Xuerong Deng, Jiahao Qu, Zhuoli Zhang. Association between triglyceride?glucose index and carotid atherosclerosis in patients with psoriatic arthritis: a cross-sectional study. Rheumatology (Oxford) 2023 Mar 10; kead100. doi: 10.1093/rheumatology/kead100

13. Lanlan Ji, Mingyue Wang, Rui Wang, Jingyang Dang, Zhuoli Zhang. A lupus patient with multiple lichenoid papules. Arthritis & Rheumatology 2023 Aug;75(8):1356-1357. doi: 10.1002/art.42479

14. Wenhui Xie, Hong Huang, Zhuoli Zhang. Dynamic Characteristics and Predictive Profile of Glucocorticoids Withdrawal in Rheumatoid Arthritis Patients commencing glucocorticoids with csDMARD. Rheumatology & Therapy 2023,10:405-419 DOI 10.1007/s40744-022-00527-9

15. Xiaohui Zhang, Lanlan Ji, Haoze Zhang, Juan zhao, Zhuoli Zhang. Successful Treatment of Rituximab in a Steroid-dependent Adult IgA Vasculitis Patient with gastrointestinal involvement. Scandinavinia Journal of Rheumatology 2023; 2023 May;52(3):324-325

16. Yan Geng, Yong Fan, Yu Wang, Xuerong Deng, Guangtao Li, Juan Zhao, Lanlan Ji, Xiaohui Zhang, Zhibo Song, Haoze Zhang, Xiaoying Sun, Dai Gao, Wenhui Xie, Hong Huang, Yanni Gui, Zhuoli Zhang. Flare and changes in disease activity among inactive rheumatoid arthritis patients following COVID-19 vaccination in China: A prospective cohort analysis. Chin Med J 2023;136(19):2324–2329.

17. Juan Zhao, Wei Zhou, Yangfeng Wu, Ping Ji, Xiaoyan Yan, Li Yang, Zhuoli Zhang. The efficacy, safety, and cost-effectiveness of conventional synthetic disease-modifying anti-rheumatic drugs triple therapy in preventing relapse in rheumatoid arthritis patients: a randomized controlled trial (ESCoRT study). Chin Med J 2022 Sep 20;135(18):2200-2209.

18. Borui Li, Hong Huang, Juan Zhao, Xuerong Deng, Zhuoli Zhang. Discrepany in Metabolic syndrome bewteen Psoriatic Arthritis than Rheumatoid Arthritis: a direct comparison of two cohorts in one center. Rheumatology & Therapy 2023 Feb;10(1):135-148.

19. Yan Geng, Zhibo Song, Xiaohui Zhang, Xuerong Deng, Yu Wang and Zhuoli Zhang. Improved diagnostic performance of CASPAR criteria with integration of ultrasound. Frontiers in Immunology 2022 Oct 10;13:935132. doi: 10.3389/fimmu.2022.935132 

20. Juan Zhao, Zhuoli Zhang. Effective Therapy of Pirfenidone in A Patient with Idiopathic Retroperitoneal Fibrosis: report of a case. Clinical Rheumatology Clin Rheumatol 2023 Feb;42(2):591-595

21. Yu Wang, Zhibo Song, Shuang Zhang, Xiaojuan Yu, Yonggang Cui, Zhuoli Zhang. Primary amyloidosis presenting as unusual cutaneous nodules diagnosed by 18F-FDG PET/CT aided biopsy: a case report. Qjm: An International Journal of Medicine 2023 Mar 27;116(3):237-238.

22. Wenhui Xie, Yu Wang, Shiyu Xiao, Yang Yu, Wei Wang, Lin Qiu, Zhuoli Zhang. Association of Gestational Diabetes Mellitus with Overall and Type-Specific Cardio-Cerebrovascular Diseases: Systematic Review with Meta-Analysis involving 8,116,780 participants. BMJ 2022 Sep; 378: e070244.  

23. Weijian Zhang, Zhuoli Zhang. Lupus Pernio in Sarcoidosis. NEJM 2022 Aug 11;388(6):546 DOI: 10.1056/NEJMicm2118330

24. Juan Zhao, Zhuoli Zhang. Syndecan-4 is highly expressed in rheumatoid arthritis patients and positively related with disease activity of rheumatoid arthritis. Advances in Rheumatology 2022;62:21

25. Deng, Xuerong; Sun, Xiaoying; Xie, Wenhui; Wang, Yu; Zhang, Zhuoli. The correlation of ultrasound-detected synovitis in an individual small joint with overall clinical disease activity in patients with rheumatoid arthritis. Clinical Rheumatology 2022;41(11): 3319-3324

26. Liujun Wang, Fong Fan, Yanni Gui, Xinlei Yang, Xia Ye, Yongping Cao, Zhuoli Zhang. Endoplasmic reticulum stress triggered autophagy and regulated the phenotype transformation of rheumatoid arthritis synovial fibroblasts via the IRE1/JNK pathway. Annals of Translational Medicine 2022;10(13):725

27. Borui Li, Guangtao Li, Zhibo Song, Zhuoli Zhang. Serum Calprotectin as a Promising Inflammatory Biomarker in Psoriatic Arthritis：A One-year Longitudinal Study. Rheumatology & Therapy 2022

28. Borui Li, Guangtao Li, Xinlei Yang, Zhibo Song, Yu Wang, Zhuoli Zhang. NETosis in Psoriatic Arthritis: Serum MPO-DNA Complex Level Correlates with its Disease Activity. Frontiers in Immunology 2022;13:911347

29. Wenhui Xie, Lanlanji, Zhuoli Zhang. Sirolimus monotherapy for thrombocytopenia in primary antiphospholipid syndrome: a pilot study from a tertiary referral center. Frontiers in Immunology 2022;13:857424

30. Wenhui Xie, Hong Huang, Zhuoli Zhang. Incidence of and risk factors for paradoxical psoriasis or psoriasiform lesions in inflammatory bowel disease patients receiving anti-TNF therapy: A systematic review and meta-analysis. Frontiers in Immunology 2022;13:847160

31. Hong Hong, Yu Wang, Wenhui Xie, Yan Geng, Dai Gao, Zhuoli Zhang. Impact of treat-to-target therapy on bone mineral density loss in patients with rheumatoid arthritis: a prospective cohort study. Frontiers in Endocrinology, section Bone Research 2022;13: 867610

32. Hong Huang, Wenhui Xie, Yan Geng, Yong Fan, Juan Zhao, Zhuoli Zhang. Towards a better treat-to-target strategy in rheumatoid arthritis: A comparion of two real-wold cohorts. Rheumatology and Therapy 2022 Mar 28;1-11. doi: 10.1007/s40744-022-00441-0

33. Geng Y, Gao T, Zhang X, Wang Y, Zhang Z. The association between disease duration and mood disorders in rheumatoid arthritis patients. Clin Rheumatol. 2022 Mar;41(3):661-668. doi: 10.1007/s10067-021-05967-2.

34. Lanlan Ji, Dai Gao, Yanjie Hao, Yu Wang, Xuerong Deng, Yan Geng, Zhuoli Zhang. Low-dose glucocorticoid withdrawn in systemic lupus erythematosus: a desirable and attainable goal. Rheumatology (Oxford) 2022 DOI: 10.1093/rheumatology/keac225

35. Lanlan Ji, Wenhui Xie, Serena Fasano, Zhuoli Zhang. Risk factors of flare in patients with systemic lupus erythematosus after glucocorticoids withdrawal. A systematic review and meta-analysis. Lupus Sci Med. 2022;9(1):e000603. 

36. Xiaoying Sun, Lanlan Ji, Guangtao Li, Lin nong, Wei Zhang, Wenhui Xie, Zhuoli Zhang. Eyelid erythema as the first manifestation of subcutaneous panniculitis-like T-cell lymphoma mimicking dermatomyositis: a case-based review. Clinical Rheumatology. Clin Rheumatol. 2022;41(3):929-934.

37. Yong Fan，Dai Gao, Zhuoli Zhang. Telitacicept for systemic lupus erythematosus. Drug Today 2022,58(1):23-32

38. Yong Fan, Yan Geng, Yu Wang, Xuerong Deng, Guangtao Li, Juan Zhao, Lanlan Ji, Xiaohui Zhao, Zhibo Song, Haoze Zhang, Xiaoying Sun, Dai Gao, Wenhui Xie, Hong Huang, Yanjie Hao, Zhuoli Zhang. Safety and disease flare of autoimmune inflammatory rheumatic diseases: a large real-world survey on inactivated COVID-19 vaccines. Ann Rheum Dis. 2022;81(3):443-445

39. YanJie Hao, Lanlan Ji, Dai Gao, Yong Fan, Yan Geng, Xiaohui Zhang, Guangtao Li, ZhuoLi Zhang. The rate and factors determining flare occurrence in systemic lupus erythematosus patients who achieved low disease activity or remission: results from a prospective cohort study. Lupus Science & Medicine. 2022 Mar;9(1):e000553. 

40. Yanjie Hao, Shereen Oon, Lanlan Ji, Dai Gao, Yong Fan, Yan Geng, Xiaohui Zhang, Guangtao Li, Eric Francis Morand, Mandana Nikpour, Zhuoli Zhang. Determinants and protective associations of the lupus low disease activity state in a prospective Chinese cohort. Clinical Rheumatology 2022; Feb;41(2):357-366

41. Lemei An, Tianshu Chu, Liujun Wang, Songtao An , Yalong Li, Hongbo Hao, Zhuoli Zhang, Han Yue. Frequent injections of high-dose human umbilical cord mesenchymal stem cells slightly aggravate arthritis and skeletal muscle cachexia in collagen-induced arthritic mice. Exp Ther Med. 2021;22(5):1272.   

42. Zhibo Song, Xuerong Deng, Wenhui Xie, Borui Li, Zhuoli Zhang. Clinical characteristics of psoriatic arthritis in Chinese patients: a cross?sectional study. Rheumatology & Therapy 2021;8:1845–1857

43. Yu Wang, Zhi-Bo Song, Xue-Rong Deng, Xiao-Hui Zhang, Zhuoli Zhang. Risk factors associated with osteoporosis and fracture in psoriatic arthritis. Chinese Medical Journal 2021;134(21):2564-2572 PMID:34670248

44. Dai Gao, Yanjie Hao, Fan Yong, Lanlan Ji and Zhuoli Zhang. Predicting lupus low disease activity state and remission in SLE: novel insights. Expert Review of Clinical Immunology. 2021;17(10):1083-1089

45. Juan Zhao, Wei Zhou, Yangfeng, Ping Ji, Xiaoyan Yan, Li Yang, Zhuoli Zhang. The efficacy, safety and cost-effectiveness of hydroxychloroquine, sulfasalazine, methotrexate triple therapy in preventing relapse among rheumatoid arthritis patients in low disease activity: the study protocol of a randomized controlled clinical trial. BMC Medical Informatics and Decision Making. 2021;21(1):83.

46. Yong Fan, Wenhui Xie, Hong Huang, Guangtao Li, Yan Geng, Yanjie Hao, Zhuoli Zhang. Association of immune related adverse events with efficacy of immune checkpoint inhibitors and overall survival in advanced cancers: a systemic review and meta-analysis. Frontiers in Oncology, section Cancer Immunity and Immunotherapy 2021;15(1):33-42

47. Yong Fan, Yanjie Hao, Dai Gao, Lan Gao, Guangtao Li, and Zhuoli Zhang. Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model. Clinical and Experimental Pharmacology and Physiology. 2021;70(2):213-226

48. Hong Huang, Lin Mu, Zhuoli Zhang, Yanjie Hao, Wei Zhou. Therapeutic choices and outcomes in Chinese patients with serologically active clinically quiescent systemic lupus erythematosus: a retrospective observational study. Arthritis Res Ther. 2021;23(1):275.

49. Hong Huang, Wenhui Xie, Yan Geng, Yong Fan, Zhuoli Zhang. Mortality in patients with primary Sj?gren’s syndrome: A systematic review and meta-

50. Hong Huang, Yanjun Gong, Li Guo, Zhuoli Zhang. Insidious coronary artery disease in?a young patient with polyarteritis?nodosa: a case report and review of literature. BMC Cardiovascular Disorders. 2021;21(115):1-7

51. Hong Huang, Zhuoli Zhang, Juan Zhao, Yanjie Hao, Wei Zhou. The effectiveness of treatments for patients with SAPHO syndrome: a follow-up study of 24 cases from a single center and review of literature. Clin Rheumatol. 2021;40(3):1131-9.

52. Lanlan Ji, Wenhui Xie, Zhuoli Zhang. Low-dose glucocorticoids should be withdrawn or continued in systemic lupus erythematosus? A systematic review and meta-analysis on risk of flare and damage accrual. Rheumatology 2021;60(12):5517–26

53. Wenhui Xie, Guangtao Li, Hong Huang, Zhuoli Zhang. How to Define Boolean-Low Disease Activity: A Study of a Chinese Single Center Experience. Rheumatology and Therapy 2021;8(1):289-301

54. Wenhui Xie, Hong Huang, Guangtao Li, Yanjie Hao, Yanni Gui, Yu Wang, Xuerong Deng, Juan Zhao, Yan Geng, LanLan Ji, Xiaohui Zhang, Zhibo Song, Zhuoli Zhang. The dynamical trajectory of glucocorticoid tapering and discontinuation in rheumatoid arthritis patients commencing glucocorticoids with csDMARDs: a real-world data from 2009 to 2020. Ann Rheum Dis. 2021;80:997–1003.

55. Wenhui Xie, Hong Huang, Siyan Zhan, Zhuoli Zhang. Risk of psychiatric disorders and all- cause mortality with belimumab therapy in patients with systemic lupus erythematosus: a meta-analysis of randomised controlled trials. Lupus Science & Medicine 2021;8:e000534.

56. Wenhui Xie, Hong Hunag, Zhuoli Zhang. Maternal and Neonatal Outcomes in Women with Psoriasis and Psoriatic Arthritis: A Meta-Analysis of Observational Studies. Rheumatology (Oxford) 2021,60(9):4018–4028