timi天美传孟若羽

团队介绍：

团队现有在职工作人员10余人，长期从事肝胆胰外科临床与基础研究，目前课题组在读研究生20余人，注重人才培养及团队建设，长期与北京大学医学部生化实验室、国家纳米科学中心等保持密切协作。先后10余人次赴德国乌尔姆大学进修学习。

项目情况：

连续获得八次“国家自然科学基金”资助, 6项已结题，1项在研

叁项“北京市自然科学基金”资助，2项已结题，1项在研

两项“首都临床特色应用研究项目”，均已结题

招生信息（拟招生的研究方向）：

肝胆胰外科临床与基础研究

科研项目：

1. 国家自然科学基金面上项目, 82171722, 胰腺癌细胞外泌体活化肝星状细胞重塑预转移小生境促进肝转移的免疫机制研究, 2022/01 至 2025/12, 58万元, 在研, 主持

2. 北京市自然科学基金,面上项目, 7212111, 星形细胞外泌体 miR-5703抑制TIMP-2调控胰腺癌细胞干性转化的机制研究, 2021-01 至 2023-12, 20万元, 在研, 主持

3. 国家自然科学基金面上项目，81871954，BRG1/miR-485-3p/PAK1轴调控胰腺癌细胞迁移、侵袭及干性维持的机制研究，2019/01-2022/12，58万元，已结题，主持。

代表性研究成果：

1. Wei, Dan; Cheng, Xiaoyu; Du, Chong; Wang, Yazhou; Sun, Jingyi; Li, Chen; Wu, Jing; Tian, Xiaodong; Zhao, Ying*; Nie, Guangjun*; Yang, Yinmo*; Stroma-targeted nanoparticles that remodel stromal alignment to enhance drug delivery and improve the antitumor efficacy of Nab-paclitaxel in pancreatic ductal adenocarcinoma models, NANO TODAY, 2022, 45: 101533.

2. Chen, Kai; Wang, Yazhou; Hou, Yuting; Wang, Qi; Long, Di; Liu, Xinxin; Tian, Xiaodong*; Yang, Yinmo*; Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancer, Cancer Letter, 2022 Oct. 545:215834.

3. Chen K, Wang Q, Li MZ, Guo HH, Liu WK, Wang F, Tian XD*, Yang YM*; Single cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression, EBioMedicine, 2021, 55:103315.

4. Wang, Yazhou; Du, Chong; Zhao, Ying*; Nie, Guangjun*; Yang, Yinmo*; Trap and kill strategy for non-BRCA mutant pancreatic cancer by co-delivery of olaparib and JQ1 with plectin-1 targeting peptide nanoparticles, NANO TODAY, 2020. 33: 100877.

5. Li, Mingzhe; Guo, Huahu; Wang, Qi; Chen, Kai; Marko, Kornmann; Tian, Xiaodong; Yang, Yinmo*; Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway, Cancer Lett. 2020 Oct 10, 490: 20-30.

6. Du, Chong; Qi, Yingqiu; Zhang, Yinlong; Wang, Yazhou; Zhao, Xiao; Min, Huan; Han, Xuexiang; Lang, Jiayan; Qin, Hao; Shi, Quanwei; Zhang, Zhengkui; Tian, Xiaodong ; Anderson, Greg J; Zhao, Ying*; Nie, Guangjun*; Yang, Yinmo*; Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 ( BRCA2) Mutation, ACS Nano. 2018 Nov 27; 12 (11): 10785-10795.

7. Wang F, Rong L, Zhang Z, Li M, Ma L, Ma Y, Xie X, Tian X*, Yang Y*. LncRNA H19-Derived miR-575-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway. J Cancer. 2020: 11(15):4771-4782.

8. Zhang Z, Li J, Guo H, Wang F, Ma L, Du C, Wang Y, Wang Q, Kornmann M, TianX*, Yang Y*; BRM transcriptionally regulates miR-302a-3p to target SOCS5/STAT3 signaling axis to potentiate pancreatic cancer metastasis. Cancer Lett. 2019, 449: 215-225.

9. Ma L, Wang F, Du C, Zhang Z, Guo H, Xie X, Gao H, Zhuang Y, Kornmann M, Gao H, Tian X*, Yang Y*. Long non-coding RNA MEG3 functions as a tumour suppressor and has prognostic predictive value in human pancreatic cancer, Oncol Rep, 2018, 39 (3): 1132-1140.