timi天美传孟若羽

团队介绍：

王东信教授担任timi天美传孟若羽麻醉科主任，北京大学第一临床学院临床医学研究所副所长。学术兼职包括中国心胸血管麻醉学会副会长、中国研究型医院协会麻醉学专业委员会常务委员、中华医学会麻醉学分会委员、中国医师协会麻醉学医师分会委员等。任《国际麻醉学与复苏杂志》、《础苍别蝉迟丑别蝉颈辞濒辞驳测中文版》等着名期刊常务编委。王东信教授以第一及通讯作者身份发表厂颁滨论文120余篇。研究领域涵盖术前预测与预康复、术中精准麻醉管理、术后优化镇静镇痛等；在围术期并发症、分娩镇痛等方面取得系列原创性成果。

项目情况：

先后主持和承担973项目、国家重点研发项目、国家自然科学基金重大项目等课题。近五年承担国家级及省部级项目如下：

1. 2023国家自然科学基金重大项目：围术期老年脑功能稳态失衡风险预测模型的建立及精准麻醉策略研究，课题4。项目批准号：82293644。经费：400万元。2023.1-2027.12。

2. 2018年国家重点研发项目：老年围术期风险分级与差异化管理技术方案研究。编号：2018YFC2001800。经费：450万元。2018.12.31-2022.12.31。（该项目已结题，目前已发表39篇SCI论文，培养14名硕士/博士研究生，科研成果丰硕）

3. 首都特色研究基金(2018-1-4071)：右美托咪定辅助镇痛对老年恶性肿瘤病人术后谵妄发生率和远期存活的影响：随机、双盲、安慰剂对照研究。经费：100万元。

招生信息（拟招生的研究方向）：

老年患者围术期脑保护；

围术期精准管理与器官保护；

围术期管理与远期结局；

分娩镇痛与母婴预后。

科研项目：

围术期老年脑功能稳态失衡风险预测模型的建立及精准麻醉策略研究；

右美托咪定辅助镇痛对老年恶性肿瘤病人术后谵妄发生率和远期存活的影响：随机、双盲、安慰剂对照研究。

代表性研究成果：

1. Cao SJ, Zhang Y, Zhang YX, Zhao W, Pan LH, Sun XD, Jia Z, Ouyang W, Ye QS, Zhang FX, Guo YQ, Ai YQ, Zhao BJ, Yu JB, Liu ZH, Yin N, Li XY, Ma JH, Li HJ, Wang MR, Sessler DI, Ma D, Wang DX; First Study of Perioperative Organ Protection (SPOP1) investigators. Long-term survival in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: follow-up of a multicentre randomised trial. Br J Anaesth. 2023 Aug;131(2):266-275. doi: 10.1016/j.bja.2023.01.023. Epub 2023 Jun 4.

2. Cao SJ, Zhang Y, Zhang YX, Zhao W, Pan LH, Sun XD, Jia Z, Ouyang W, Ye QS, Zhang FX, Guo YQ, Ai YQ, Zhao BJ, Yu JB, Liu ZH, Yin N, Li XY, Ma JH, Li HJ, Wang MR, Sessler DI, Ma D, Wang DX; First Study of Perioperative Organ Protection (SPOP1) investigators. Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. Br J Anaesth. 2023 Aug;131(2):253-265. doi: 10.1016/j.bja.2023.04.024. Epub 2023 Jun 4.

3. Enlund M, Berglund A, Enlund A, Lundberg J, W?rnberg F, Wang DX, Ekman A, Ahlstrand R, Flisberg P, Hedlund L, ?stlund I, Bergkvist L; CAN-study group. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. EClinicalMedicine. 2023 Jun 9;60:102037. doi: 10.1016/j.eclinm.2023.102037. eCollection 2023 Jun.

4. Zhang Y, Cui F, Ma JH, Wang DX. Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. Br J Anaesth. 2023 Aug;131(2):385-396. doi: 10.1016/j.bja.2023.05.001. Epub 2023 Jun 9.

5. Xu LL, Wang C, Deng CM, Dai SB, Zhou Q, Peng YB, Shao HY, Han YQ, Yu J, Liu CH, Xia F, Zhang SQ, Wang DX, Chen XZ. Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery: A Randomized Clinical Trial. JAMA Netw Open. 2023 Apr 3;6(4):e239321. doi: 10.1001/jamanetworkopen.2023.9321.

6. Wang K, Su X, Ma JH, Wang DX. Optimal strategy for delirium detection in older patients admitted to intensive care unit after non-cardiac surgery. Front Surg. 2023 Mar 27;10:1095329. doi: 10.3389/fsurg.2023.1095329.

7. Li S, Wang DX, Zhao P, Luo A. Editorial: The mechanism and interventions of aging-related cognitive impairment in perioperative context. Front Aging Neurosci. 2023 Mar 24;15:1174890. doi: 10.3389/fnagi.2023.1174890. eCollection 2023.

8. Xing MW, Li CJ, Guo C, Wang BJ, Mu DL, Wang DX. Effect of intraoperative dexmedetomidine on long-term survival in older patients after major noncardiac surgery: 3-year follow-up of a randomized trial. J Clin Anesth. 2023 Jun;86:111068. doi: 10.1016/j.jclinane.2023.111068.

9. Butris N, Tang E, He D, Wang DX, Chung F. Sleep disruption in older surgical patients and its important implications. Int Anesthesiol Clin. 2023 Apr 1;61(2):47-54. doi: 10.1097/AIA.0000000000000391.

10. Xu ZZ, Li X, Chen BL, Yang KL, Wang J, Li XY, Zhang H, Wang DX. A randomised controlled trial of the non-inferiority of erector spinae plane block vs. thoracic paravertebral block for laparoscopic nephro-ureterectomy. Anaesthesia. 2023 Apr;78(4):442-448. doi: 10.1111/anae.15959. Epub 2023 Jan 4.