timi天美传孟若羽

团队介绍：

潘义生教授，主任医师，博士生导师。主持国家自然科学基金一项，发表中英文论文20余篇。研究方向包括感染性休克肠道屏障功能的保护和预防。

项目情况：

致力于外科感染性休克疾病的治疗和预防，重点关注大肠杆菌Nissle1917对感染性休克肠屏障功能的保护作用及机制研究，获得国家自然科学基金面上项目资助，曾在国际期刊Journal of Experimental & Clinical Cancer Research、Life Sciences等期刊上发表科学论文。

招生信息（拟招生的研究方向）：

肠道屏障

科研项目：

国家自然科学基金委员会, 面上项目, 81970459, 大肠杆菌属Nissle1917通过激活TLR4-MYD88通路对感染性休克肠屏障功能的保护作用及机制研究

代表性研究成果：

(1) Mei Feng; Hao Xu; Wenyuan Zhou; Yisheng Pan ; The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma, Journal of Experimental & Clinical Cancer Research, 2023, 42(1): 44

(2) Hao Xu; Qisheng Hou; Jing Zhu; Mei Feng; Pengyuan Wang; Yisheng Pan ; The protective effect of Escherichia coli Nissle 1917 on the intestinal barrier is mediated by inhibition of RhoA/ROCK2/MLC signaling via TLR-4, Life Sciences, 2022, 292: 120330

(3) Yurong Wang; Lie Sun; Shanwen Chen; Shihao Guo; Taohua Yue; Qisheng Hou; Mei Feng; Hao Xu; Yucun Liu; Pengyuan Wang; Yisheng Pan; The administration of Escherichia coli Nissle 1917 ameliorates irinotecan-induced intestinal barrier dysfunction and gut microbial dysbiosis in mice., Life sciences, 2019, 231: 116529

(4) Shihao Guo; Shanwen Chen; Ju Ma; Yongchen Ma; Jing Zhu; Yuanyuan Ma; Yucun Liu; Pengyuan Wang; Yisheng Pan ; Escherichia coli Nissle 1917 Protects Intestinal Barrier Function by Inhibiting NF-κB-Mediated Activation of the MLCK-P-MLC Signaling Pathway, Mediators of Inflammation, 2019, 2019: 5796491

(5) Shihao Guo; Zhihao Huang; Jing Zhu; Taohua Yue; Xin Wang; Yisheng Pan; Dingfang Bu; Yucun Liu; Pengyuan Wang; Shanwen Chen ; CBS-H2S axis preserves the intestinal barrier function byinhibiting COX-2 through sulfhydrating human antigen R in colitis, Journal of Advanced Research,2022, 44(2023): 201-212