timi天美传孟若羽

团队介绍：

本团队主要科研方向为胃肠道肿瘤发病和治疗的分子机制。所研究的课题主要集中在：慢性炎症在胃肠道肿瘤发生发展中的作用；结直肠癌肿瘤免疫微环境的调控机制及新型治疗靶点的选择。主持多项国家自然科学基金和北京市自然科学基金项目研究。这些研究聚集前沿，基础与临床相结合，研究成果具有较强的创新性,为探寻结直肠癌免疫治疗新策略提供了理论依据，具有临床转化价值。

项目情况：

承担国家自然科学基金叁项，北京市自然科学基金二项

招生信息（拟招生的研究方向）：

拟招生研究方向：胃肠道肿瘤发病和治疗的分子机制；炎症性肠病的发病机制和干预措施

科研项目：

1.结直肠癌中罢搁笔痴1促进罢细胞功能障碍和免疫逃逸的机制

2.罢搁笔痴1调控线粒体代谢促进罢细胞耗竭的机制及其对结直肠癌免疫治疗效果的影响

3.结直肠癌中笔础搁2对肿瘤免疫微环境的调控作用及其机制

4.炎症性肠病中调节性罢细胞功能障碍的机制及其靶向治疗

代表性研究成果：

· Guigen Teng#, Zilin Liu#, Yun Liu, Ting Wu, Yun Dai*, Huahong Wang*, Weihong Wang*. Probiotic Escherichia coli Nissle 1917 Expressing Elafin Protects Against Inflammation and Restores the Gut Microbiota. Front Microbiol. 2022 May 6;13:819336.

· Jiang X#, Wang C#, Ke Z, Duo L, Wu T, Wang W, Yang Y, Dai Y*. The ion channel TRPV1 gain-of-function reprograms the immune microenvironment to facilitate colorectal tumorigenesis. Cancer Lett. 2022 Feb 28;527:95-106.

· Duo L#, Wu T#, Ke Z, Hu L, Wang C, Teng G, Zhang W, Wang W, Ge Q, Yang Y*, Dai Y*. Gain of function of ion channel TRPV1 exacerbates experimental colitis by promoting dendritic cell activation. Mol Ther Nucleic Acids. 2020;22:924-936.

· Ke Z, Wang C, Wu T, Wang W, Yang Y, Dai Y*. PAR2 deficiency enhances myeloid cell-mediated immunosuppression and promotes colitis-associated tumorigenesis. Cancer Lett. 2020;469:437-446

· Wu T#, Wang C#, Wang W, Hui Y, Zhang R, Qiao L*, Dai Y*. Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis. Oncoimmunology. 2018;7(11):e1498437.

· Teng G#, Dai Y#, Chu Y, Li J, Zhang H, Wu T, Shuai X, Wang W*. Helicobacter pylori induces caudal-type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells. Cancer Sci. 2018;109(2):297-307.

· Wu T, Dai Y*, Wang W, Teng G, Jiao H, Shuai X, Zhang R, Zhao P, Qiao L*. Macrophage targeting contributes to the inhibitory effects of embelin on colitis-associated cancer. Oncotarget. 2016;7(15):19548-19558.

· Dai Y*, Jiao H, Teng G, Wang W, Zhang R, Wang Y, Hebbard L, George J, Qiao L*. Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. Mol Cancer Ther. 2014;13(5):1206-1216.

· Dai Y#, Wilson G#, Huang B#, Peng M, Teng G, Zhang D, Zhang R*, Ebert MP, Chen J*, Wong BC, Chan KW, George J, Qiao L*. Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer. Cell Death Dis. 2014;5(4):e1170.